Endocrine Abstracts

Introduction: Myxedema coma is the end stage of untreated or inadequately treated hypothyroidism. It has an estimated incidence of 0.22 per million per year. The clinical picture is often that of an elderly obese female, presenting in midwinter with increased lethargy, somnolence and confusion. The presentation is one of severe hypothyroidism, with or without coma.Such cases are predominantly based on a primary thyroid disorder such as Hashimoto′s ...

Cushing’s syndrome results from an excess exposure to glucocorticoids which can result from various causes, divided into ACTH-dependent and ACTH-independent etiologies. An example of ACTH-independent causes are adrenal masses which are either benign adenomas, representing the majority of adrenal mass cases, or by malignant neoplasms. We present the case of a 52 yo woman who presented at the Emergency Department (ER) with thoracic pain and palpitations, for which several c...

Introduction: The prevalence of functioning gonadotropinoma is difficult to assess since most of reports are case reports. Gonadotropinomas rarely lead to a noticeable clinical syndrome. They usually produce symptoms associated with mass effect such as headaches, visual field impairment and hormonal deficiencies.Case report: We present the case of a 38 years old women diagnosed in 2017 with microprolactinoma. She had elevated prolactin level (108 ng/ml) ...

Introduction: Remission after transsphenoidal surgery in patients with acromegaly is confirmed by biochemical assays of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Although their levels are usually closely correlated, discordant results of these tests have been noted, making the follow-up of acromegaly patients particularly challenging.Case report: We present the case of a 35 year old female diagnosed with acromegaly at the age of 32 ye...

Introduction: Medullary thyroid cancer is a rare neuroendocrine tumor arising from the parafollicular C cells of the thyroid gland. Calcitonin production is a characteristic feature of medullary thyroid cancer and preoperative high levels indicate an increased risk of local and distant metastatic disease. Although rare, Horner syndrome could be caused by metastatic medullary thyroid cancer. Horner syndrome usually presents with ptosis, miosis and facial anhidrosis and most of ...

Introduction: De Quervain’s thyroiditis, also known as subacute granulomatous thyroiditis, is a self-limiting inflammatory disorder of the thyroid gland. It is presumed to be caused by a viral infection and many patients have a history of an upper respiratory infection 2-8 weeks prior to the onset of thyroiditis. It is the most common cause for neck pain or discomfort, and it usually has a predictable course of thyroid function evolution. On ultrasonography the thyroid gl...

Introduction: Primary adrenal lymphoma is a rare cause of adrenal insufficiency, with most cases being of B-cell lymphoma.Case report: We present the case of a 51 yo man with a 1.5-month history of recurrent fever, nausea, vomiting, anorexia, weight loss of 12 kg, fatigue, polyarthalgia, hypotensive episodes (70/40 mmHg) and singultus. Before admission in our clinic he had a thoracic CT scan, which showed a 5.5 cm right adrenal mass and hyperplasia of th...

Introduction: Although patients with inflammatory bowel disease (IBD) -Crohn’s disease (CD) and ulcerative colitis (UC)- are considered prone to malnutrition, studies have shown an increased risk for obesity, especially visceral obesity and metabolic syndrome (MetS). Possible mechanisms involved include dysbiosis, gut microbiome and chronic inflammation. The aim of the study was to assess the prevalence of MetS and obesity in a group of IBD patients.<p class="abstext"...

Background: Quality of life (QoL) has become a useful outcome in recent studies among different specialties. In Cushing’s syndrome, elevated cortisol levels result in a decreased QoL, the cause for this impairment being multifactorial. More studies are necessary to find modifiable factors where doctors could intervene and thus improve QoL.Objective: To evaluate QoL in a group of Romanian patients with Cushing’s syndrome. Design: We performed a ...

Primary vaginal malignancy is uncommon, accounting for about 2% of all gynecological tract cancers, with small-cell neuroendocrine carcinoma of the vagina being exceptionally rare and aggressive. They display similar histological and immunohistochemical features to small-cell carcinomas of different origin. Few cases are reported in the literature so far and therefore, there is no current treatment protocol consensus. We report the case of a 34-year-old nulliparous patient, wh...